H-1B Legal Win: A federal judge in Boston struck down Trump’s $100,000 H-1B visa fee as an unlawful tax needing congressional approval, after chaos last September as workers rushed to beat the deadline—good news for Massachusetts schools, universities, and healthcare employers that rely on international talent. Workforce Pressure: A new Boston Indicators/MassInc Policy Center report warns Massachusetts may need 60,000 new immigrants annually through 2030 to avoid labor shortages, with health care and higher education among the most exposed sectors. Biotech & Cancer Care: Curium, PeptiDream, and PDRadiopharma completed patient dosing in a Japan Phase 2 trial of 64Cu-PSMA-I&T for prostate cancer, aiming for future regulatory submission. Rare Disease Research: JW Pharmaceutical presented new preclinical results on DDC-02 for multiple neurodevelopmental disorders at an orphan drug conference in Boston. Public Health & Aging Science: Boston-based Life Biosciences is testing a gene-therapy approach using “partial reprogramming” to potentially regenerate eye nerve cells for glaucoma in an early clinical trial. Local Health System Moves: Dana-Farber is set to build a Brighton outpatient center, expanding access closer to patients. Community Health Support: Acton’s “Team Barry” effort helped a deaf, nonverbal 76-year-old secure safer housing and basic needs after police and fire found serious living conditions. Sports & Wellness Culture: Ipswich High boys lacrosse forfeited a state semifinal after photos of players smoking cigars sparked a dispute over Massachusetts’ chemical health rules. Energy & Climate: Massachusetts lawmakers are pushing geothermal heating/cooling incentives as a potential way to cut building emissions and utility costs.